A curse can ruin your life completely.
curse is any expressed wish that some form of adversity or misfortune will befall or attach to one or more persons, a place, or an object. In particular, “curse” may refer to such a wish or pronouncement made effective by a supernatural or spiritual power, such as a god or gods, a spirit, or a natural force, or else as a kind of spell by magic or witchcraft; in the latter sense, a curse can also be called a hex or a jinx. In many belief systems, the curse itself or accompanying ritual is considered to have some causative force in the result. To reverse or eliminate a curse is sometimes called “removal” or “breaking”, as the spell has to be dispelled, and is often requiring elaborate rituals